Toll-Like Receptor Stimulation but before Clonal Expansion Is Impacted by Occurring Early after Antigen Presentation T Cell Clonal Conditioning: A Phase
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چکیده
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T cell clonal conditioning: a phase occurring early after antigen presentation but before clonal expansion is impacted by Toll-like receptor stimulation.
After in vivo immunization, Ag-specific T cells disappear from circulation and become sequestered in lymphoid tissue where they encounter Ag presented by dendritic cells. In the same site and just after Ag presentation, they "disappear" a second time and we investigated this process. Using a mouse model of T cell deletion (without Toll-like receptor (TLR) stimulation) vs survival (with TLR stim...
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تاریخ انتشار 2003